⚡ Acute Severe Migraine Treatment 🦠 First-Line Options 📍 Triptans (5-HT1B/1D agonists): Sumatriptan (oral, nasal, SC), rizatriptan, eletriptan - abort migraine by causing cerebral vasoconstriction and blocking pain pathways - most effective within 2 hours of onset 📍 CGRP antagonists (gepants): Ubrogepant, rimegepant (oral) - block CGRP receptor, no vasoconstriction - safe alternative when triptans contraindicated (CV disease, uncontrolled HTN) 🦠 Second-Line/Combination Therapy 📍 NSAIDs (hig