mTOR will make you bigger: The mTOR pathway is a central regulator of metabolism with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain. The activation of TORC1 activation is required for myofibrillar muscle protein synthesis and skeletal muscle hypertrophy in humans in response to both physical exercise and ingestion of certain amino acids or amino acid derivatives. Here is a very good lecture by David Sabatini about the regulation

Cancer starts when normal biological signals in the body go haywire, also known as dysregulation. In breast cancer, one of the most common signals that can go haywire is called PI3K, which controls how cells grow and stay healthy. Learn more from our Lead Medical Director, Jennifer Schutzman who uses everyday objects to explain this critical pathway in breast cancer and efforts to target it more precisely than ever before. Learn more and watch the full video series: https://www.gene.com/stories/