Researchers have identified two FDA-approved cancer drugs, letrozole and irinotecan, that reversed Alzheimer’s-related brain ...

Background Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic cancer with highly variable malignant potential. Current understanding of their biology remains ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Proliferating cell nuclear antigen (PCNA) is a central regulator of numerous cellular ...

Scientists at Northwestern University have developed a large open-access database to support early-stage drug development. The tool is designed to help researchers better understand diseases and ...

Using single-cell transcriptomics to reveal CD226 upregulation and enhancement of CD19-CAR-T function in the inhibitory CNS microenvironment of refractory CNS lymphoma. A phase I/II study to assess ...

Secondary analysis of omic datasets holds great potential in accelerating precision oncology research and drug development. Yet, scientists lack efficient tools to assess the scope and volume of those ...

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...

Paired single-cell and spatial resolved transcriptomics (SRT) data supplement each other, providing in-depth insights into biological processes and disease mechanisms. Previous SRT databases have ...