Frontiers

Immunopathology in PMM2-CDG: Defective glycosylation impact in the TNFα -TNFR1 signalling pathway

Glycosylation is a post-translational modification that plays a crucial role in immune system activity. Phosphomannomutase 2-Congenital Disorder of Glycosylation (PMM2-CDG) is a rare genetic disease ...
Nature

RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function

Although several ribosomal protein paralogs are expressed in a tissue-specific manner, how these proteins affect translation and why they are required only in certain tissues have remained unclear.
C&EN

Ion Conduction Mechanisms in Potassium Channels Revealed by Permeation Cycles

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
Nature

The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Fig. 2: The level of GlcAT-II activity in EXTL3∆N preparations exhibits substantial dependence on the level of EXT1 contamination. Fig. 4: The GT64 domain of EXTL3 shows high similarity with that of ...
PNAS

Structure and mechanism of the human CTDNEP1–NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology

Here, we examine mechanisms by which a noncanonical membrane protein phosphatase, CTDNEP1 (C-terminal Domain Nuclear Envelope Phosphatase 1), is regulated by its transmembrane regulatory subunit, ...