Single-cell transcriptomics can profile thousands of cells in a single experiment and identify novel cell types, states and dynamics in a wide range of tissues and organisms. Standard experimental ...

The heart and brain are among the earliest and most metabolically demanding organs in human development. Though historically studied in isolation, both ...

Researchers have produced the most detailed map yet of how stem cells in the growing tip of a plant begin their journey to form the many cell types that shape flowers and stems. They identified 18 ...

Since their early association with atopic disease, granulocytes, particularly eosinophils, have been widely used as biomarkers, yet the mechanisms underlying their role in airway and atopic ...

We developed a statistical method for Integrative and Reference-Informed Spatial Domain Detection for Spatial Transcriptomics. IRIS is a reference-informed integrative method for detecting spatial ...

The complex landscape of cardiovascular diseases encompasses a wide range of related pathologies arising from diverse molecular mechanisms and exhibiting heterogeneous phenotypes. This variety of ...

In recent years, single-cell transcriptomics has opened a new frontier in microbiology. By revealing gene expression heterogeneity at the individual-cell level, this technology allows researchers to ...