13hon MSN
Toward experiment-guided AlphaFold: Researchers overcome AI tool's single-conformation limitation
The AI-based program AlphaFold predicts a protein's 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and ...
The model learns that hedging is a signal of lower-quality output. This creates a systematic bias toward sounding certain.
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