Liquid-like histone H1 'glues' nucleosomes, reshaping how DNA compacts

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" ...
IEEE

DHAG-DTA: Dynamic Hierarchical Affinity Graph Model for Drug-Target Binding Affinity Prediction

Abstract: Computational methods for predicting drug-target binding affinity (DTA) are critical for large-scale screening of prospective therapeutic compounds during drug discovery. Deep neural ...
Search Engine Roundtable

Google Shopping Crawlers Are Too Fast For JavaScript Generated Structured Data

14 months ago, Google updated its documentation around its shopping related structured data warning not to generate your structured data dynamically through JavaScript. Yesterday, at the Search ...
PNAS

Retraction for Murmu et al., Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E

The undersigned authors note, “This article is being retracted on the recommendation of the University of Kansas Medical Center Office of Research Integrity, following an investigation that found ...
GEN

TF Binding Mapped via DynaTag in Single Cells, Low-Input Samples

Mapping transcription factor (TF) binding sites across the genome is key to understanding how cells control gene expression, yet pinpointing their footprints across the genome—especially in single ...
C&EN

Ligand Exchange and Binding at the Surface of PbS Quantum Dots Quantified Using Multimodal Magnetic Resonance

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Semiconductor quantum dots (QDs) show promise for various applications, including ...
PNAS

Dynamic binding of the bacterial chaperone Trigger factor to translating ribosomes in Escherichia coli

Translation of the genetic code into proteins by ribosomes is essential for life. Due to the risk of protein misfolding, ribosomes require assistance from cotranslational processing factors, but how ...
C&EN

Combination of Autodisplay and Dynamic Pharmacophore Modeling Reveals New Insights into Cyclic Nucleotide Binding in Hyperpolarization-Activated and Cyclic Nucleotide-Gated Ion ...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play a critical role in regulating neuronal and cardiac rhythmicity, with their function being modulated by cyclic nucleotide ...