Co‑injecting three common amino acids with LNPs dramatically boosted both mRNA delivery and CRISPR gene editing efficiency in preclinical models.

Human genes are written in long strings of three-letter units composed of four different nucleotides. These units—or ...

Scientists at UC Berkeley have discovered a microbe that bends one of biology’s most sacred rules. Instead of treating a specific three-letter DNA code as a clear “stop” signal, this methane-producing ...

Lipid nanoparticles, or LNPs, are best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of ...

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Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution.

Ozempic has been making headlines for its remarkable success in treating obesity and diabetes. Yet it is just one in a rapidly growing class of drugs called peptide therapeutics that sits between ...

A recent study by Fred Hutch biochemist Christopher Lapointe, PhD, and his colleagues, uses innovative lab techniques to ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest questions. Consisting of amino acids strung together into peptide chains, these ...

Proteins are biopolymers of amino acids (polypeptides), joined by peptide bonds, that are generated by ribosomes. The amino acid sequence, encoded by its gene, determines a protein’s structure and ...

Glycogen storage disease type III (GSD III; McKusick, 232,400) is an autosomal recessive disease caused by the deficiency of glycogen-debranching enzyme (amylo-1,6-glucosidase, AGL). AGL contains two ...