Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

Medical evidence comes in the form of population statistics, but patients behave like people, each one unique. Physicians ...

States have responded to increasing health care consolidation by enhancing their review of mergers and acquisitions. But some states have carved out certain academic medical centers from such ...

Recent changes in U.S. vaccine policy are sowing confusion and threatening the health of children and the wider population.

Some foreign pharmaceutical plants that export generic drugs to the United States have glaring quality problems that can lead ...

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

European Study of Prostate Cancer Screening — 23-Year Follow-up (N Engl J Med 2025;393:1669-1680). In the “Additional Analysis” subsection of Results (page 1673), the first sentence of the second p ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 3).

To the Editor: Vitiligo is a depigmenting skin disorder that can have a substantial effect on patients’ quality of life. In their report on two phase 3 trials of ruxolitinib cream (Topical Ruxolitinib ...

To the Editor: Sanyal et al. (Oct. 21 issue)1 add important new data to our understanding of the natural course of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH). A substa ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 5).