Background The SELENA flare index (SFI) has functioned well in clinical and clinical trial settings (1), but has the limitation that it classifies only severe versus combined mild/moderate flares.

Background Significant trauma and muscular tightness often result during Total Knee Artroplasty (TKA) surgery and thus act to restrict tissue fluid movement resulting with lower extremity oedema.

Background Immunosuppressive therapy may potentially alter the natural disease course of scleroderma. There have been reports of using mycophenolate mofetil (MMF) for the treatment of scleroderma skin ...

Background Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is an acute inflammatory polyartritis and palpable pitting edema of the elderly patients. It dramatically ...

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare type of ANCA associated Vasculitis (AAVs). Cyclophosphamide (CYC) is generally recommended for the induction of remission in ...

Background: Macrophage activation plays a crucial part in synovial inflammation, a driving force in osteoarthritis (OA) [1]. Our previous research has revealed that NOD2 attenuates OA by modulating ...

F8: Back to the future: how to mix the old and new treatments for SLE, Sjögren's and APS ...

The multiple rheumatological faces of PsA (or PsA is more than just poly-arthritis? - Consequences for management in daily practice) ...

Objectives Rheumatoid arthritis (RA) has a considerable disease burden with life-long physical limitations, reduced work productivity and high societal costs. Trials on arthralgia at-risk for RA are ...

We read with interest the recent article by Singh and Cleveland on the hypersensitivity risk of allopurinol (ALP) and febuxostat (FBX) compared with colchicine.1 A common challenge when using ALP, ...

Objective Considering the diverse aetiologies and immunodysregulatory statuses observed in each patient with rheumatoid arthritis (RA), stratification based on peripheral blood immunophenotyping holds ...

Background Non-alcoholic fatty liver disease, characterised by hepatic steatosis (HS), is a major cause of chronic liver disease in many countries. Limited data are available on liver enzyme elevation ...