A wave of spatial transcriptomics studies has produced gene-expression atlases that span entire organs and whole organisms, from mouse embryos to the roundworm C. elegans to 31 human tissues. These ...

A team of researchers has constructed the most detailed single-cell map of the adult human prostate to date, cataloging more ...

Many biological functions and systems are influenced by how gene expression is spatially distributed, from subcellular through to tissue, organ, or at embryonic level. Our understanding of these ...

Nova-ST, a new spatial transcriptomics technique, has been introduced by researchers based at Vlaams Instituut voor Biotechnologie (VIB), Katholieke Universiteit (KU) Leuven. According to the ...

Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper functioning. Understanding these spatial arrangements is important when ...

Applying single-cell RNA sequencing has led researchers to be able to profile the entire transcriptome of cells. However, these transcriptomes prove difficult to link back to their original location ...

Transcriptomics is the study of the transcriptome, which is the complete set of RNA transcripts produced by the genome at a specific time or under particular conditions. It involves the analysis of ...

Researchers at the Max Delbrück Center have developed an open-source spatial transcriptomics (ST) platform, called Open-ST, that creates 3D molecular maps from patient tissue samples with subcellular ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...