Nature

Single-case experimental designs: the importance of randomization and replication

Single-case experimental designs (SCEDs) involve repeat measurements of the dependent variable under different experimental conditions within a single case, for example, a patient or a classroom 1.
Nature

Mendelian randomization study revealed a gut microbiota-neuromuscular junction axis in myasthenia gravis

Myasthenia gravis (MG) is a chronic autoimmune disease characterized by pathogenic antibodies directed against acetylcholine receptors (AChR), muscle-specific kinase (MUSK), lipoprotein-related ...
ascopubs.org

CONTACT-01: A Randomized Phase III Trial of Atezolizumab + Cabozantinib Versus Docetaxel for Metastatic Non–Small Cell Lung Cancer After a Checkpoint Inhibitor and Chemotherapy

Phase Ib Study of Unesbulin (PTC596) Plus Dacarbazine for the Treatment of Locally Recurrent, Unresectable or Metastatic, Relapsed or Refractory Leiomyosarcoma One hundred eighty-six patients were ...
Purdue University

Research Design and Ethics

Once you have determined your research question, the next step is to decide on a research design. As random assignment tends to be challenging in SoTL, most projects tend to fall into the ...
ascopubs.org

Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...