Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been ...

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such ...

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs — single-stranded RNAs involved in protein synthesis — and proteins from the same stretch of DNA, plays ...

A team of researchers has identified a mechanism that regulates the production of two different proteins from the same gene. Researchers from the Institute for Neurosciences, a joint center of the ...

A recent study highlights the pivotal role of alternative splicing in controlling plant secondary metabolism, which is crucial for producing bioactive compounds with significant medicinal and ...

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have improved in recent years, approximately 30% of patients relapse following ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...

In eukaryotic genetics, the one-gene/one-protein concept has, for the most part, breathed its last. Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly ...