HRR mutations are commonly of germline origin, with several real world studies suggesting a 23-44% probability of an HRR alteration to be of germline origin: 1 The following summarizes recommendations ...

By Tarun Sai Lomte Scientists reveal how evolution within our own tissues can drive disease, protect cells, and uncover hidden therapeutic targets for future precision medicine. Somatic genomics ...

ctDNA as a biomarker in phase II study of tepotinib in advanced solid cancers with MET exon 14 skipping mutation or amplification (KCSG AL19-17). Characterization of molecular response and progression ...

Clinical Outcomes of Adult Patients With Newly Diagnosed Mixed Phenotype Acute Leukemia Colorectal tumors that underwent somatic next-generation sequencing (NGS) for 154-168 genes in an in-house ...

Scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer. The team also uncovered hints of a potential new ...

Faculty in the Statistics in Genomics and Genetics Hub develop statistical and computational methods for analyzing high-throughput genomic and epigenomic data to advance biological discovery in cancer ...

Two months later, Gould began to experience a strange cascade of symptoms. His ankles swelled to the width of his calves. The right side of his face became so bloated that he could not open his eye.

Cancer begins when mutations in specific genes override the body’s built-in controls on cell division, allowing rogue cells ...

Characteristics of Clonal Hematopoiesis (CH) Mutations - a) We identified somatic mutations in known clonal hematopoiesis of indeterminate potential (CHIP) driver genes using peripheral blood ...