When ABC was still developing Grey's Anatomy, the network made a push to have Rob Lowe join the cast in a leading role. However, fate had other plans.

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When Rob Lowe had some hard feelings about leaving The West Wing, he turned to humor. In a TikTok posted July 24, Lowe, 61, spoke to the camera while in a storage room. “So a lot has been talked about ...

It's hard to picture anyone else taking on the role.

Rob Lowe explains why he declined the role of Derek Shepherd on Grey’s Anatomy, how Patrick Dempsey was cast, and what happened during the show’s early casting process ...

Has anyone seen Sam Seaborn? Rob Lowe, who played the idealistic deputy of communications at the White House on the first four seasons of NBC's acclaimed political drama The West Wing, asked that very ...

Rob Lowe and Tom Cruise used to be "super super super good homies." Though, apparently they weren't close enough for Cruise to talk openly about his part in Martin Scorsese's "The Color of Money." ...

"Ohio Goes to the Movies" is bringing 46 free film events statewide in March. Here's when, where and which movies are being shown.

Charlie Sheen shares stories from going to school with Sean Penn, Robert Downey Jr., and Rob Lowe before they all became Hollywood legends. The actor discusses what it was like being classmates with ...

Rob Lowe continues to find himself in hot water with sports fans. Yes, that Rob Lowe (not Rob Loe), who looks like Rob Pelinka but is the Parks and Recreation actor you know and love. After he became ...

Rob Lowe and Tom Cruise used to be “super super super good homies.” Though, apparently they weren’t close enough for Cruise to talk openly about his part in Martin Scorsese’s “The Color of Money.” ...