Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies. There is no known cure for Huntington's disease. A genetic ...

New research from scientists at the University of Birmingham and other institutions describes a method of counting labeled proteins in living cells dubbed Protein-tag Degree of Labeling (PRoDOL) that ...

Understanding how proteins behave in living systems is central to biology. Yet, for decades, researchers have relied on overexpression models or antibody-based detection methods that can distort the ...

His-tagged proteins underpin research in structural biology, test development, and drug development. Their small tag enables easy purification and rapid construct iteration. When screening many ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest ...

There is no known cure for Huntington's disease. A genetic mutation creates harmful proteins that accumulate and cause the disease's typical symptoms. A team from the Department of Human Genetics at ...

Rush hour never ceases at the nucleus’ border. Gene products begin their lives in the nucleus as strands of mRNA that ship out into the cytoplasm, where they serve as templates for protein synthesis.

Huntington's disease is a rare but severe genetic disorder caused by a mutation in the huntingtin gene. This change results in an altered variant of the huntingtin protein encoded by the gene. “It ...