Intracellular protein editing. Credit: Science (2025). DOI: 10.1126/science.adr5499. https://www.science.org/doi/10.1126/science.adr5499 University of Pennsylvania ...
Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...
Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for ...
Small but powerful: Ubiquitin controls the lifespan and distribution of proteins in the cell, but it can also determine their shape, function, or interactions with other cellular components. Ubiquitin ...
Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies. There is no known cure for Huntington's disease. A genetic ...
Understanding how proteins behave in living systems is central to biology. Yet, for decades, researchers have relied on overexpression models or antibody-based detection methods that can distort the ...
Age-related changes in protein tagging and degradation may help explain how the brain declines over time and why diet can still influence these processes.
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