Non-CHO cell expression systems gain traction as faster, more flexible alternatives for biologics manufacturing.

This article and associated images are based on a poster originally authored by Marina Fedorova and Ian Hiles and presented at ELRIG Drug Discovery 2024 in affiliation with GSK. This poster is being ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

Making proteins for research or therapies often starts with cell-line development. In many applications, genetic engineering is used to optimize a cell line for producing high levels of the intended ...

Scientists reprogrammed two widely used “chemically induced proximity” systems in a recent chemical science paper. CIP systems are very simple: when a small molecule is added, two engineered protein ...

Profiling the proteins that cells are making is a staple of studies in biology, neuroscience and related fields because the proteins a cell is expressing at a given moment can reflect the functions ...

Protein activity can be precisely regulated via subtle changes in temperature using heat-sensitive switches. Underlying this ...