The emergence of a new synthetic opioid, known as cychlorphine, is more potent than fentanyl and responsible for 19 deaths in Tennessee.

Scripps Research scientists have re-engineered fentanyl’s core structure to retain potent analgesia while limiting respiratory depression in preclinical tests – a strategy that could inform ...

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

Oxycontin (oxycodone hydrochloride) prescription medications are effective at relieving pain but carry a risk of addiction. While there's a need for novel non-opioid drugs for pain, they face clinical ...

Researchers at the Yale School of Medicine found structural and functional alterations in specific brain regions of individuals with opioid use disorder. The study's results were published today in ...

The combination of prescribed central nervous system stimulants, such as drugs that relieve ADHD symptoms, with prescribed opioid medications is associated with a pattern of escalating opioid intake, ...