Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

Clinical portfolio, informed by deep and novel synapse biology and pharmacology insights, aims to strengthen neural connections through event-driven pharmacology Lead candidate zelquistinel is ...

Family with sequence similarity 19 member A5 (FAM19A5) is a secretory protein highly expressed in the brain that regulates synapse dynamics through its interaction with leucine-rich repeat-containing ...

Establishment of neural circuits is a tightly regulated process coordinated by a series of cellular and molecular mechanisms. Within the neural circuitry electrical and chemical information is ...

A research team led by Dr. Àlex Bayés, Head of the Molecular Physiology of the Synapse Group at the Institut de Recerca Sant Pau (IR Sant Pau), has achieved what for decades had been an elusive goal: ...

The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of ...

The brain’s rules seem simple: Fire together, wire together. When groups of neurons activate, they become interconnected. This networking is how we learn, reason, form memories, and adapt to our world ...

When a person thinks, speaks, eats, walks, or just sits comfortably with all bodily systems functioning normally, the billions of cells that make up the brain and the rest of the nervous system are ...

The human brain contains nearly 86 billion neurons, constantly exchanging messages like an immense social media network, but neurons do not work alone – glial cells, neurotransmitters, receptors, and ...