The key obstacle against the cure of human and simian immunodeficiency virus (HIV/SIV) infections is the reservoir of proviruses, which are robustly incorporated into the genomes of host CD4+ T cells.

Although it is known that individuals living with HIV infection have an increased risk for cardiovascular disease, the underlying pathology behind this observation remains unclear, the authors of a ...

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to ...

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, ...

A dual-action HIV antibody–drug conjugate forces Env to open, then blocks it, boosting virus neutralization up to tenfold in ...

Reported by WHO (World Health Organization), around 39 million people worldwide were living with Human Immunodeficiency Viruses (HIV) in 2022. However, despites decades of research, HIV pathogenesis ...

Salk Institute researchers, in collaboration with National Institutes of Health (NIH) scientists, have discovered the molecular mechanisms by which human immunodeficiency virus (HIV) becomes resistant ...

For millions of people living with HIV, a daily regimen of medications is a lifelong necessity. If they stop taking the drugs ...

HIV-1 protease inhibitors (PIs) have long been central to antiretroviral therapy, directly targeting the enzyme responsible for processing viral polyproteins into functional units. Their efficacy, ...

Michael Sension, MD, provides insights on resistance mechanisms promoting MDR HIV. Ryan Haumschild, PharmD, MS, MBA: If you could, give us an overview and then discuss how this smaller patient ...

Researchers have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for ...