Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene ...

DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning ...

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and ...

The ability to control gene expression across a wide range is crucial for many fields, including bioengineering, disease ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Researchers at the School of Biological Sciences of The University of Hong Kong (HKU) have uncovered how eukaryotic cells can control gene activity even after losing one of their major gene-regulatory ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

Our circadian clocks play a crucial role in our health and well-being, keeping our 24-hour biological cycles in sync with light and dark exposure. Disruptions in the rhythms of these clocks, as with ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Less than 2% of the genome codes for proteins; the rest, once called 'junk DNA', contains regulatory elements. Researchers ...