Necroptosis is a form of programmed cell death that occurs in the absence of caspase activation and depends on the activity of the receptor-interacting protein kinases. Inactivation of these kinases ...

In a recent study posted to the bioRxiv* preprint server, researchers discovered that the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is susceptible to cleavage at ...

The concept of the present method is shown schematically. The crosslinker (pBpa, red circle) or the cleavage site (AllocLys-OH, blue circle) is introduced to Protein 1 or Protein 2, respectively.

Investigators have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced proteomic technique called N-terminomics, ...

In an effort to better understand how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) selectively targets and damages specific organs within the body upon infection, researchers have ...