Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

For decades, geneticists have known that most common illnesses are not caused by a single rogue gene but by intricate constellations of DNA variants acting together in specific cells. Now a new ...

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer. DNA is well-known for its double helix shape. But the human genome ...

New research assessing the efficacy of optical genome mapping (OGM) in a group of patients with acute leukemia has demonstrated that OGM provided reliable and robust analytical performance with high ...

New single-cell method maps protein-DNA interactions, revealing gene regulation changes and advancing multi-omics studies of health and disease. (Nanowerk News) A new technology allows scientists to ...

DNA methylation is an epigenetic modification crucial to normal development, with its dysregulation leading to various diseases including cancer. As interest in epigenomics grows, an innovative ...

A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the known number of potential regulatory elements in the genome to 2.37 million, ...

This image depicts the detection of structural variants (SVs) at low sequencing coverage in both unique and repetitive regions by genomic proximity mapping (GPM), compared with other SV-calling ...