The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...
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Scientists finally reveal the cause of agonizing statin side effects
Since statins first came to market in the late 1980s, muscle aches, weakness, and fatigue have driven many patients to ...
Managing Calcium Overload Identified as Novel Therapeutic Approach in Treating Injured Muscle Fibers
Mutations in a calcium ion channel anoctamin 5 (ANO5), commonly found in muscle cells, cause the debilitating disease called limb girdle muscular dystrophy 2L (LGMD2L). Characterized by progressive ...
IT has been postulated that calcium ions act as the link between depolarization and contraction in cardiac 1 and skeletal muscle 2. This hypothesis is based on the results of experiments relating the ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
Ferulic acid suppresses ileal smooth muscle contraction by inhibiting calcium ion influx through voltage-dependent calcium channels. This action may help prevent or treat excessive intestinal motility ...
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